Development of ICT-integrated screening tool and cost-effectiveness analysis on different modalities for early detection of biliary atresia

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19177
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical sociology
• Research Institution: St. Luke's International University
• Principal Investigator: HOSHINO Eri 聖路加国際大学, 臨床疫学センター, 講師 (50598521)
• Research Collaborator: HAYASHI Kuniyoshi 聖路加国際大学, 専門職大学院公衆衛生学研究科(公衆衛生大学院), 講師
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 胆道閉鎖症 / 早期発見 / 硫酸抱合型胆汁酸 / 便色カラーカード / 携帯アプリ / 費用対効果分析 / ICT

Outline of Final Research Achievements

To explore the effective modality for screening biliary atresia, this study includes conducting (1) a retrospective study on evaluating urinary sulfated bile acid (USBA) measure, (2) a prospective study on developing ICT-integrated screening tool, and (3) a cost-effective analysis on different modalities for biliary atresia screening. Ｔhe sensitivity of USBA measurement was 100% and the specificity was 96.2% using the Okinawa cohort study implemented from 2009-2015. As for a prospective study, we developed the iPhone application, "Baby-poop" and it was released in September 2016. The detection algorithm applied in the application was evaluated using 40 stool pictures including 5 cases of disease and both sensitivity and specificity were 100%. A cost-effectiveness analysis of the three screening methods of biliary atresia, a stool color card, USBA measurement method, and a mobile application is being conducted.

Free Research Field

臨床疫学・医療経済