2017 Fiscal Year Final Research Report
Studies on mechanisms and prevention of chemotherapy-induced peripheral neuropathy
| Project/Area Number |
16K19184
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 抗がん剤 / 末梢神経障害 / オキサリプラチン / 大腸がん / パクリタキセル / シスプラチン / ボルテゾミブ / フマル酸ジメチル |
|---|
| Outline of Final Research Achievements |
Chemotherapy agents such as platinum and taxane frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this.
In this study, we found a new drug for prevention of the chemotherapy-induced peripheral neuropathy, using screening system targeting nerve fiber degenerations. Dimethyl fumarate attenuates oxaliplatin-induced peripheral neuropathy without affecting both the anti-tumor activity and the other toxicities of oxaliplatin, in culture cells and rodents.
|
| Free Research Field |
臨床薬学
|
