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2017 Fiscal Year Final Research Report

Establishment of a sandwich ELISA for salusin-beta

Research Project

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Project/Area Number 16K19202
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionKitasato University

Principal Investigator

Fujimoto Kazumi  北里大学, 理学部, 特任助教 (50769297)

Co-Investigator(Renkei-kenkyūsha) SHICHIRI Masayoshi  北里大学, 医学部, 教授 (10206097)
KODERA Yoshio  北里大学, 理学部, 教授 (60265733)
HAYASHI Akinori  北里大学, 医学部, 助教 (30458830)
Research Collaborator KAMATA Yuji  
OGAWA Akifumi  
KATO Yukiko  
KAWASHIMA Yusuke  
SAITO Tatsuya  
Project Period (FY) 2016-04-01 – 2018-03-31
KeywordsELISA / 生理活性ペプチド
Outline of Final Research Achievements

Salusin-β was initially predicted from bioinformatic analyses in 2003. Salusin-β acutely regulates hemodynamics and chronically induces atherosclerosis, but its unique physicochemical characteristics to tightly adhere to all types of plastic and glassware have prevented elucidation of its precise pathophysiological role. In this study, we successfully established a sandwich enzyme-linked immunosorbent assay (ELISA) to quantitate plasma free full-length salusin-β concentrations. Free salusin-β levels showed circadian variation and its levels in patients with diabetes mellitus and panhypopituitarism combined with complete central diabetes insipidus showed significantly lower than healthy controls.

Free Research Field

病態検査学

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Published: 2019-03-29  

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