Effect of antimicrobial peptide cathelicidin on atopic dermatitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19217
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Juntendo University
• Principal Investigator: Umehara Yoshie 順天堂大学, 医学研究科, 博士研究員 (40707072)
• Research Collaborator: KAMATA Yayoi 順天堂大学, 大学院・医学研究科, 助教 (00410035) ; MATSUDA Hironori 順天堂大学, 大学院・医学研究科, 技術員 ; NIYONSABA Francois 順天堂大学, 国際教養学部, 教授 (60365640) ; TOMINAGA Mitsutoshi 順天堂大学, 大学院・医学研究科, 准教授 (50468592)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 難治性かゆみ / アトピー性皮膚炎 / 抗菌ペプチド / カテリシジン / アトピー性皮膚炎モデルNC/Ngaマウス

Outline of Final Research Achievements

We investigated the effect of antimicrobial peptide cathelicidin on atopic dermatitis (AD). Following induction of AD-like symptoms on NC/Nga mice, cathelicidin mCRAMP ointment was applied to the lesional skin. Although dermatitis scores and scratching behavior were not suppressed, stratum corneum hydration was improved by the ointment. We also found that expressions of calpain I and BH mRNA in epidermis were increased. These data suggest that increased NMFs by upregulation of NMF-generating proteases improve stratum corneum hydration.

Free Research Field

かゆみ科学、分子発生学