Association between maternal dioxin levels during pregnancy and genetic polymorphisms on infant epigenetic effects

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19243
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Hokkaido University
• Principal Investigator: KOBAYASHI Sumitaka 北海道大学, 環境健康科学研究教育センター, 特任講師 (10733371)
• Research Collaborator: MIYASHITA Chihiro 北海道大学, 環境健康科学研究教育センター, 特任准教授 (70632389) ; ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 妊婦 / 胎児 / ダイオキシン類 / DNAメチル化 / エピゲノム / 遺伝環境交互作用 / 環境化学物質 / 公衆衛生学

Outline of Final Research Achievements

Using prospective birth cohort, I examined an association between maternal dioxin levels in blood during pregnancy and genetic polymorphisms of genes encoded dioxin-metabolizing receptor and enzymes (aromatic hydrocarbon receptor [AHR], cytochrome P450 [CYP] 1A1, CYP1A2, CYP1B1, and glutathione S-transferase mu1 [GSTM1]) on levels of infant DNA methylation (insulin-like growth factor-2 [IGF-2], H19, and long interspersed nuclear element-1 [LINE-1]). None of maternal genotypes showed the effects of infant IGF-2, H19, and LINE-1 methylation levels for maternal dioxin levels during pregnancy. In conclusion, maternal genetic polymorphisms of genes encoded dioxin-metabolizing receptor and enzymes did not modify the association between maternal dioxin levels in blood during pregnancy and levels of infant IGF-2, H19, and LINE-1 methylation.

Free Research Field

疫学（環境疫学・分子遺伝疫学）・予防医学、衛生学・公衆衛生学