Search for predictive biomarkers on mood changes of bipolar disorder by metabolome analysis.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19257
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Osaka City University
• Principal Investigator: DEGUCHI YASUHIKO 大阪市立大学, 大学院医学研究科, 講師 (30721790)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 双極性障害 / 自殺予防 / バイオマーカー / うつ病

Outline of Final Research Achievements

The increased levels of nervonic acid in patients with major depressive disorder (MDD) compared with controls and patients with bipolar disorder (BD). Nervonic acid levels were increased in the depressive state in patients with MDD compared with the levels in the remission state in patients with MDD and the depressive state in patients with BD. Circulating mitochondrial DNA (mtDNA) levels showed a positive correlation with IL-4 in patients with MDD. Patients with MDD and BD showed significantly lower plasma mtDNA levels than controls. We collected plasma samples from depressive state and remitted state of the same BD patients and matched healthy controls. We analyzed the metabolites and there was no significant difference in metabolites between the groups.

Free Research Field

うつ病、双極性障害、産業精神医学

Academic Significance and Societal Importance of the Research Achievements

血漿ネルボン酸が、うつ病の状態像を示すバイオマーカー候補、うつ病と双極性障害の鑑別に寄与するバイオマーカー候補となりうる可能性が示された。ミトコンドリアDNAがうつ病の炎症に関与している可能性が示された。