• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Final Research Report

Development of gene therapy for liver cirrhosis utilizing MMP13

Research Project

  • PDF
Project/Area Number 16K19333
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionNiigata University

Principal Investigator

Yokoo Takeshi  新潟大学, 医歯学総合研究科, 特任助教 (80750629)

Research Collaborator OGAWA kohei  
KOBAYASHI yoko (SHINAGAWA yoko)  
KAMIMURA kenya  
OBA yoshihiko  
YOSHINO hideyoshi  
OTSUKA masato  
ODA masafumi  
Liu Dexi  
TERAI shuji  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords肝硬変 / MMP13 / ハイドロダイナミック遺伝子導入法
Outline of Final Research Achievements

MMP13 is one of enzyme, which has the possibility of ameliorating liver fibrosis. We evaluated whether gene therapy using MMP13 could resolve liver cirrhosis of rat. Hydrodynamic gene delivery of MMP13 to the cirrhotic liver showed to suppress progression of liver fibrosis in the rats with continuous stimulation to cause liver inflammation and fibrosis. In addition, the delivery also demonstrated to decrease fibrotic tissue in the rats without the stimulation.

Free Research Field

遺伝子治療

Academic Significance and Societal Importance of the Research Achievements

肝線維化は高度進行例でなければ、肝内の炎症を鎮めることである程度の改善が期待できる。逆に進行した場合には回復が難しいことが知られており、point of no returnなどと表現される。本研究では、MMP13遺伝子導入の炎症が継続する肝内における線維化抑制効果、また、炎症収束後の肝内における線維化改善効果が示されており、肝硬変診療の新たな治療手段となり得ることを示したものであり、今後の肝硬変診療発展の基盤となり得ると考える。

URL: 

Published: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi