Elucidation of the pathological condition of non-alcoholic fatty liver disease regarding retinoid receptor signaling

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19336
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: Shirakmai Yohei 岐阜大学, 大学院医学系研究科, 助教 (50632816)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 非アルコール性脂肪性肝炎 / レチノイド / 糖尿病 / 脂肪肝

Outline of Final Research Achievements

Retinoid receptor signaling is focused to elucidate the pathological condition of non-alcoholic fatty liver disease (NAFLD). Transgenic mice, in which retinoic acid receptor (RAR) or retinoid X receptor (RXR) is dominant-negatively inhibited, were generated and the phenotypes were investigated. Steatohepatitis and glucose intolerance were exacerbated in RXR-transgenic mice fed high-fat diet. The signaling of RXR is thought to play important roles in development and progression of NAFLD and glucose metabolism.

Free Research Field

消化器病学