2017 Fiscal Year Final Research Report
identifying the antigen of IgG4 related disease
| Project/Area Number |
16K19339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kobe University (2017)
Kyoto University (2016) |
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Principal Investigator |
Shiokawa Masahiro 神戸大学, 科学技術イノベーション研究科, 特別研究員(PD) (50737880)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | IgG4 |
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| Outline of Final Research Achievements |
Subcutaneous injection of patient IgG, but not control IgG, resulted in pancreatic and salivary gland injuries. Pancreatic injury was also induced by injecting patient IgG1 or IgG4, with more destructive changes induced by IgG1 than by IgG4. The potent pathogenic activity of patient IgG1 was significantly inhibited by simultaneous injection of patient IgG4. Binding of patient IgG, especially IgG1 and IgG4, to pancreatic tissue was confermed in both the mouse model and AIP tissue samples. Next, we identified this target antigen as laminin 511.
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| Free Research Field |
消化器内科
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