2018 Fiscal Year Final Research Report
The development of non-invasive method for the molecular diagnosis
| Project/Area Number |
16K19345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Liquid biopsy / 胆汁 / 胆嚢癌 / Circulating tumor DNA / ctDNA / リキッドバイオプシー / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
Tissue diagnosis is essential in gastrointestinal cancer such as gastric cancer, colon cancer, pancreatic cancer and gallbladder cancer. However, tissue sampling is challenging in some cases because of the anatomy. In the development of non-invasive nucleic acid mutation analysis technology (liquid biopsy), which is the subject of this research, we focus on circulating tumor DNA (ctDNA) of blood or body fluid. We proved the possibility of gallbladder cancer diagnosis from bile and established a new approach.
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| Free Research Field |
消化器内科学
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| Academic Significance and Societal Importance of the Research Achievements |
胆嚢癌の癌細胞中の情報が胆汁中にも存在していることを証明した。この知見から新たな診断方法として、胆汁中の遺伝子変異を検出する新たな手法を確立した。診断が困難な胆嚢癌に対して、非侵襲的な新たな方法の一つとなりうると思われる。
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