2017 Fiscal Year Final Research Report
| Project/Area Number |
16K19357
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
|
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| Research Institution | Yokohama City University |
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Principal Investigator |
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 腸内細菌 / 非アルコール性脂肪肝炎 |
|---|
| Outline of Final Research Achievements |
Up to 25% of NAFLD patients develop a progressive inflammatory liver disease termed non-alcoholic steatohepatitis (NASH) that may progress towards cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. In recent years, several lines of evidence suggest that the gut microbiome plays important roles for the pathogenesis of NASH. We demonstrated faecalibacterium (FB) was significantly decreased with exacerbated liver fibrosis in human study. The aim of our study was to assess if FB improves NASH pathogenesis in mice and mechanism between FB and improving NASH-pathogenesis. Our study indicated that FB-administration improves NASH pathogenesis via ameliorating gut-permeability by inducingTreg in colon. Our results suggest that FB could be a candidate agent for the treatment of NASH through the improving leaky-gut.
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| Free Research Field |
腸内細菌と非アルコール性脂肪肝
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