2017 Fiscal Year Final Research Report
the novel molecular mechanism of the regulation of cardiac macrophages
| Project/Area Number |
16K19387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 心不全 / マクロファージ / 慢性炎症 |
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| Outline of Final Research Achievements |
Heart failure is still a disease with high morbidity and high mortality and the elucidation of the pathophysiology is imperative. We have previously revealed that murine cardiac resident macrophages are indispensable in homeostasis of heart, and Amphiregulin, which is expressed exclusively in cardiac macrophages has a cardio-protective role. I performed ATAC-seq of cardiac macrophages to analyze the transcriptional regulation of these cell-specific genes. As compared to heart failure model and aged mice, I found that the epigenome of cardiac macrophages has altered in the transition from fetal liver monocyte-derived to bone marrow monocyte-derived and with aging of bone marrow. I think the intervention to the molecular mechanism which led to these epigenomic changes could be the novel target of heart failure.
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| Free Research Field |
循環器内科学
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