Identification and functional analysis for molecule X via comprehensive genetic analysis

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kanazawa University
• Principal Investigator: Tada Hayato 金沢大学, 附属病院, 助教 (90623653)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 家族性高コレステロール血症

Outline of Final Research Achievements

We found that rare as well as deleterious mutations in genes known as causative genes for recessive lipid disorders were associated with increased LDL cholesterol level among Japanese patients with hyper LDL cholesterolemia.

Free Research Field

循環器遺伝学

Academic Significance and Societal Importance of the Research Achievements

本邦における高LDLコレステロール血症において、これまでの知見と比較し多彩な遺伝子異常が寄与することを見出した。従って、このような背景を検討するにあたっては、網羅的なスクリーニングシステムを使用する必要がある。