Establishment of the strategy of transplantation with cardiomyocyte-committed progenitors

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19402
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: MASAFUMI TAKEDA 京都大学, iPS細胞研究所, 研究員 (40547501)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 心筋前駆細胞 / 心筋再生

Outline of Final Research Achievements

We successfully found that human-induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM)-committed progenitors (CCPs) that express CD82, almost exclusively differentiate into CMs both in vitro and in vivo. Ｗe examined the effect of transplanted CD82+ CCPs to rat MI model. As a result, we observed transplanted CD82+ CCPs exclusively differentiated into CMs wihtin injured hearts and the beneficial effect on improving cardiac function. Although, unfortunately, we could not maintain and expand the CD82+ CCPs with the conbination of growth factors and singal inhibitors for maintaining and expanding cardiovasucular progenitors reported elsewhere, CD82+ CCPs should serve as a promising cells source for cardiac regeneration.

Free Research Field

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