Homeostatic maintenance system of circulation via platelet micro RNA.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19422
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Jichi Medical University
• Principal Investigator: Sakata Asuka 自治医科大学, 医学部, 助教 (90528457)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 血小板 / microRNA

Outline of Final Research Achievements

The aim of this study was to clarify the role of micro RNA within platelets.
Micro RNA within platelets decreased upon platelet aging and platelet activation. The quantity of RNA within platelets correlated with activation ability of the platelets. These results were observed both experiments using human platelets and experiments using mouse platelets. RNA poor platelets were increased inside the mouse having endothelial injury. From the database analysis, there is a possibility that the micro RNA decreasing by platelet activation affect the thrombus formation and inflammatory response.
Utilizing this micro RNA, we may able to establish a new therapeutic strategy that can control thrombotic reaction and inflammatory response. Quality check of transfusion platelets and risk assessment of thrombosis of individual patient becomes possible by quantifying RNA within platelets.

Free Research Field

血栓止血