2018 Fiscal Year Final Research Report
A study of role of phospholipid metabolism in cardiovascular diseases
| Project/Area Number |
16K19436
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 心血管病 / 急性大動脈解離 / リン脂質代謝 / ホスホリパーゼA2 |
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| Outline of Final Research Achievements |
This study was aimed to examine a possible role of secreted phospholipase A2 (sPLA2) in cardiovascular diseases, and to develop a new stratagy to prevent from cardiovascular diseases. As a result, group V sPLA2 is the major sPLA2 isoform expressed in aortic endothelial cells, releases oleic and linoleic acid in response to angiotensin II stimulation, and protects against acute aortic dissection in a manner dependent upon lysyloxidase-dependent extra cellular matrix stabilization.
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| Free Research Field |
心血管病とリン脂質代謝
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| Academic Significance and Societal Importance of the Research Achievements |
急性大動脈解離は循環器領域を代表する重篤で予後不良な疾患であるが、病態を反映する動物モデルがほとんどなく、発症メカニズムに迫る報告は極めて限られている。今回の研究によって、V型分泌性ホスホリパーゼA2を起点とするリン脂質代謝が急性大動脈解離を抑制する作用を有することが明らかとなった。今後、リン脂質代謝を標的とした急性大動脈解離の新たな治療・予防法の開発が期待できる。
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