Development of treatment strategies for Pulmonary Alveolar Microlithiasis using an animal model

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19460
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: Saito Atsushi 札幌医科大学, 医学部, 助教 (00768939)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 肺胞微石症 / 動物モデル / ナトリウムリン酸共輸送体 / 治療法開発 / 肺胞マクロファージ / 肺サーファクタント

Outline of Final Research Achievements

There was no effective treatment for alveolar microlithiasis. So we tried to developing the treatment strategies using our animal model in this research. LPD prevents progressive microlith accumulation in young Npt2b-/- mice and reverses stone burden in Npt2b-/- mice. On the other hands, there was a little side effect with this treatment. Additionally, Tomocube 3D microscope revealed that microlithes were present in alveolar macrophages from Npt2b-/- mice. Alveolar macrophage seems to play an important role in the metabolism of calcium phosphate microlithes.

Free Research Field

呼吸器内科学