2017 Fiscal Year Final Research Report
Development of a new therapy for obstructive sleep apnea due to continuous negative pressure loading in the front cervical soft tissue
| Project/Area Number |
16K19469
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 閉塞性睡眠時無呼吸症候群 / CO2換気応答 / 無呼吸低呼吸指数 |
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| Outline of Final Research Achievements |
An abnormal ventilation drive was pointed out with relation to the condition of childhood obstructive sleep apnea syndrome (OSAS), and CO2 ventilatory response (HCVR) at awake was measured and examined by adult OSAS. As a result, the arousal HCVR was enhanced as severe OSAS. Apnea hypopnea index (AHI) and percutaneous CO2 value did not correlate, and exhaled CO2 value became lower as severe. There was no correlation between percutaneous and exhaled CO2. In the obese group, the CO 2 concentration in the body during sleep was high, but the respiratory variation decreased. In the OSAS group with obstructive ventilatory impairment, mean sleep exhalation CO2 value decreased and respiratory variation increased.
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| Free Research Field |
睡眠呼吸障害
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