Adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19470
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka Medical College
• Principal Investigator: Kotani Takuya 大阪医科大学, 医学部, 講師 (80411362)
• Research Collaborator: Ii Masaaki 大阪医科大学, 医学部, 講師 (10442922)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 脂肪幹細胞 / 間質性肺炎 / 膠原病

Outline of Final Research Achievements

Adipose-derived stem cells (AdSCs) have recently been considered a useful treatment tool for autoimmune disease because of their anti-inflammatory and immunosuppressive effects. We investigated the therapeutic effect of intravenous AdSC transplantation in a mouse model of bleomycin-induced lung injury. AdSCs inhibited both inflammation and fibrosis in the lung, markedly improving the survival rate of mice in a cell number-dependent manner. AdSCs inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-12 in activated macrophages by inducing apoptosis. AdSCs inhibited the differentiation and proliferation of Th2-type mCD4+ T cells but promoted the differentiation and proliferation of regulatory T cells, suggesting that the phenotypic conversion of T cells may be one of the mechanisms for the anti-inflammatory effect of AdSCs on pulmonary fibrosis. These findings suggest that intravenous AdSCs could be a promising treatment for patients with interstitial pneumonia.

Free Research Field

呼吸器、膠原病