2017 Fiscal Year Final Research Report
Pathogenesis of collagenofibrotic glomerulopathy
| Project/Area Number |
16K19488
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
GOTO Shunsuke 神戸大学, 医学部附属病院, 助教 (40457057)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 慢性腎不全 / ヒアルロン酸 / グリコサミノグリカン |
|---|
| Outline of Final Research Achievements |
In order to clarify the pathogenesis of rare kidney disease collagenofibrotic glomerulopathy, we investigated the causes of marked elevation of serum hyaluronan levels in this disease. Our results have demonstrated that molecular weight of increasing serum hyaluronan was under 100 kDa. In addition, serum levels of core protein of chondroitin sulfate was markedly increased in patients with collagenofibrotic glomerulopathy. On the other hand, either the hyaluronan synthase, hyaluronidase, TGF-beta, or IL-4 was not associated with collagenofibrotic glomerulopathy.
|
| Free Research Field |
腎臓内科学
|
