The relationship of paternal overnutrition to renal disfunction in offspring.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19502
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kurume University
• Principal Investigator: Yamada Nana 久留米大学, 医学部, 助教 (70770022)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 腎障害 / 父親の過栄養

Outline of Final Research Achievements

We examined renal injury of offspring due to paternal overnutrition. Male Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating, and kept each diet during the gestation and lactation period. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. In HFF-offspring, appetite stimulation was recognized, the weight and albuminuria increased from about 8 weeks of age. HFF-offspring developed hyperlipidemia, hyperglycemia, and hypertension. Adiponectin decrease were observed at 16 weeks old in HFF-offspring. Paternal overnutrition may cause impaired glucose tolerance and renal impairment of the offspring in future. To elucidate the mechanism, we focus on adiponectin and investigate. We will evaluate histological glomerular disorders including local adiponectin expression by immunostaining, and add epigenetics analysis.

Free Research Field

腎臓内科学