Analysis of inflammasomes in innate immunity of neuromyelitis optica

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19505
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Niigata University
• Principal Investigator: SAJI Etsuji 新潟大学, 医歯学総合病院, 助教 (00706418)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 視神経脊髄炎 / 自然免疫 / インフラマソーム

Outline of Final Research Achievements

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). The detection of NMO IgG autoantibody, which targets the aquaporin-4 water channel, distinguishes NMO from multiple sclerosis. The mRNA levels of inflammasome related genes were increased in active frozen spinal cord tissues of NMOSD. Moreover, sorted lymphocytes from peripheral blood in patients with NMOSD also had the increased mRNA expression of inflammasome related genes and interferon-gamma. These data suggest that innate immunity including inflammasome play an might important role in the pathomechanism of NMOSD.

Free Research Field

神経免疫