Drug screening for suppression of alpha-synulcein expression

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19509
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: Uemura Maiko 京都大学, 医学研究科, 特定研究員 (00767395)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Ryosuke 京都大学, 大学院医学研究科臨床神経学, 教授 (90216771) ; UEMURA Norihito 京都大学, 大学院医学研究科臨床神経学, 特定助教 (90749045)
• Research Collaborator: OKUDA Shinya 京都大学, 大学院医学研究科臨床神経学, 大学院生 ; TAGUCHI Tomoyuki 京都大学, 大学院医学研究科臨床神経学, 大学院生 ; TAMANO Ryotaro 京都大学, 大学院医学研究科臨床神経学, 技術補佐員
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: パーキンソン病 / α-シヌクレイン / 薬剤スクリーニング

Outline of Final Research Achievements

We performed drug screening using 15 compounds of similar structure and 60 compounds of similar action to compound A and B. We found that the compounds with a certain aromatic ring have potential to suppress alpha-synuclein expression.
At the same time, we developed mouse model which showed alpha-synuclein propagation more rapidly and dramatically. Next, we will infuse the compounds to the brain of alpha-synuclein-propagation mouse model to see the effect of the compounds in vivo.

Free Research Field

パーキンソン病