2017 Fiscal Year Final Research Report
Elucidation of pathogenesis and development of new therapy for neurological disorder in multiple sclerosis
| Project/Area Number |
16K19518
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
TAKEI Kohtaro
TANAKA Fumiaki
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | LOTUS / Nogo / Nogo受容体 / 多発性硬化症 / 神経変性 |
|---|
| Outline of Final Research Achievements |
We elucidated the function of LOTUS, which is the functional molecule associated with neuron, in the immune system and its dynamics in the nervous system. In the immune system, we clarified that unknown molecule X expressed on lymphocytes, which is the receptor bound to LOTUS, is involved in the pathogenesis of multiple sclerosis through the secretion of cytokines. On the other hands, in the nervous system, we revealed the fluctuation of LOTUS expression by inflammation at the mRNA level, leading to mechanism of inflammation causing neurodegeneration in multiple sclerosis. Furthermore, proteomics analysis was performed to identify candidates for unknown molecule X. These results lead to the presentation of new therapeutic targets for integrated treatment in both the immune system and the nervous system and lead to the development of new therapies that have never been thought before.
|
| Free Research Field |
神経免疫、神経変性
|
