2017 Fiscal Year Final Research Report
Role of adipocyte oxidative stress in obesity
| Project/Area Number |
16K19536
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
Okuno Yosuke 大阪大学, 医学系研究科, 助教 (10534513)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 酸化ストレス / 脂肪組織 / 糖尿病 |
|---|
| Outline of Final Research Achievements |
Adipocyte-specific elimination of oxidative stress resulted in healthy expansion of subcutaneous adipose tissue, reduction of mesenteric adipose tissue, improvement of liver steatosis and insulin resistance under high-fat diet.
Adipocybe-specific augmentation of oxidative stress resulted in reduction of white adipose tissues, acceleration of liver steatosis, whitening of brown adipose tissue and worsened insulin resistance.
Treatment of reactive oxygen species decreased gene expression of lipogenic genes and transcriptional activity of SREBP1.
|
| Free Research Field |
糖尿病
|
