2017 Fiscal Year Final Research Report
The role of inflammasome in prolonged inflammation of atherosclerosis
| Project/Area Number |
16K19544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 動脈硬化 / マクロファージ / 炎症 / 細胞死 |
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| Outline of Final Research Achievements |
NLRP3 inflammasome is a multiple cytoplasmic protein complex which is involved in innate immune response. In response to various DAMPs such as cholesterol crystals and saturated fatty acids, NLRP3 inflammasome regulates caspase-1 activation and subsequent IL-1beta processing. In this study, we aimed to clarify the role of NLRP3 inflammasome in prolonged inflammation of atherosclerosis. In order to investigate this issue, we developed inducible caspase-1 knockout mice using Cre-loxP system in an apoe-deficient background. The developed model is expected to be a useful tool to analyze the mechanisms of prolonged inflammation of atherosclerosis.
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| Free Research Field |
代謝学
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