2017 Fiscal Year Final Research Report
The metabolic effect and pathophysiological role of skeletal muscle AMPK in streptozocin-induced diabetic mice
Project/Area Number |
16K19549
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
|
Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center (2017) National Institute for Physiological Sciences (2016) |
Principal Investigator |
Yokota Shigefumi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究員 (50725281)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | AMPK / streptozotocin / 臓器連関 / myokine / IL-6 / myonectin / leptin |
Outline of Final Research Achievements |
AMP kinase (AMPK) is a metabolic sensor that plays an important role in obesity and diabetes. It was observed that found that streptozotocin (STZ)-induced diabetic mice activated AMPK in skeletal muscle. Skeletal muscle-specific dominant negative AMPK-expressing transgenic mice (DN-AMPK Tg mice) suppressed metabolic abnormalities in STZ-induced insulin-deficient diabetes. The study revealed that IL-6, myonectin, leptin and etc affect metabolic abnormalities of STZ-induced diabetes.
|
Free Research Field |
代謝・内分泌学
|