The metabolic effect and pathophysiological role of skeletal muscle AMPK in streptozocin-induced diabetic mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19549
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center (2017); National Institute for Physiological Sciences (2016)
• Principal Investigator: Yokota Shigefumi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究員 (50725281)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: AMPK / streptozotocin / 臓器連関 / myokine / IL-6 / myonectin / leptin

Outline of Final Research Achievements

AMP kinase (AMPK) is a metabolic sensor that plays an important role in obesity and diabetes. It was observed that found that streptozotocin (STZ)-induced diabetic mice activated AMPK in skeletal muscle. Skeletal muscle-specific dominant negative AMPK-expressing transgenic mice (DN-AMPK Tg mice) suppressed metabolic abnormalities in STZ-induced insulin-deficient diabetes. The study revealed that IL-6, myonectin, leptin and etc affect metabolic abnormalities of STZ-induced diabetes.

Free Research Field

代謝・内分泌学