2017 Fiscal Year Final Research Report
Understanding of molecular mechanism for overgrowth of the cells in adrenal zona glomerulosa
| Project/Area Number |
16K19550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Ryo 東北大学, 医学系研究科, 助教 (80733815)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 遺伝子発現制御 / 内分泌 |
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| Outline of Final Research Achievements |
The bioactive peptide angiotensin II causes hyperplasia in the zona glomerulosa of adrenal gland. Relationship between Ang II stimulation and hyperproliferation of the adrenal cells is still unclear. In this study, we showed that one of CREM isoforms inducible cAMP early repressor (ICER), which is known as a transcriptional repressor, is induced by Ang II in adrenal cell line. And ICER may be responsible for a negative feedback mechanism suppressing adrenal hyperproliferation by Ang II stimulation.
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| Free Research Field |
分子生物学
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