2017 Fiscal Year Final Research Report
Analysis of the novel IL-27 signaling pathway involved in homeostasis of dendritic cells
| Project/Area Number |
16K19571
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
KAJITA Mihoko 東京医科歯科大学, 難治疾患研究所, 特任助教 (00607442)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | dendritic cells / WSX-1 |
|---|
| Outline of Final Research Achievements |
In mice deficient for WSX-1, which is a component of IL-27 receptor, the number of dendritic cells (DCs) substantially decreased in lymphoid tissues and the mice developed systemic autoimmune diseases with age (Kajita et al. unpublished data). In this study, I found that DC development in the bone marrow culture was profoundly suppressed in aged WSX-1-deficient mice compared with young WSX-1-deficient mice. Moreover, IFN-γ treatment of bone marrow cells inhibited Flt3-induced DC development. IFN-γ treatment also suppressed Flt3 expression on the lineage negative cells in vitro. These data suggest that in aged WSX-1-deficient mice, the reduction of DCs in lymphoid tissues is caused by the aberrant development of DCs.
|
| Free Research Field |
免疫学, 分子腫瘍学
|
