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2017 Fiscal Year Final Research Report

Elucidation of the molecular mechanism of megakaryocyte-lineage differentiation focusing on lncRNAs

Research Project

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Project/Area Number 16K19578
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKyushu University

Principal Investigator

Miyawaki Kohta  九州大学, 大学病院, 助教 (50774709)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywords巨核球 / 前駆細胞
Outline of Final Research Achievements

Recent studies revealed that platelets and megakaryocytes contribute not only to hemostasis but also to various pathological conditions including cardio-vascular diseases, inflammatory diseases, and tumors. However, the development pathway for megakaryocyte- and platelet-lineage has been poorly understood, especially in human hematopoiesis. In the present study, we first identified prospectively-isolatable and functionally homogeneous human megakaryocyte progenitor residing near hematopoietic stem cells in human adult bone marrow. This newly-identified unipotent megakaryocyte progenitor significantly contributes normal megakaryopoiesis and pathogenesis of hematologic malignancies such as myeloproliferative diseases.

Free Research Field

造血器腫瘍

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Published: 2019-03-29  

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