Functions of dendritic cell subsets in graft versus host diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19585
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Wakayama Medical University
• Principal Investigator: Fukuda Yuri 和歌山県立医科大学, 医学部, 特別研究員 (40770847)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 樹状細胞 / サブセット / 遺伝子改変マウス / 移植片対宿主病 / 抗体

Outline of Final Research Achievements

I have investigated whether or how pathogenesis of graft versus host diseases (GVHD) depends on a dendritic cell subset, XCR1+DC, which is known to be involved in activation of cytotoxic T cells. First, I established the analyzing system for GVHD. Then by utilizing control or XCR1-DTA mice, in which XCR1+DCs are constitutively ablated, I have found that donor-derived XCR1+DCs are involved in pathogenesis of GVHD.

Free Research Field

免疫学