2017 Fiscal Year Final Research Report
Research on the pathogenesis of hand-foot syndrome focosing on cathepsin C
| Project/Area Number |
16K19702
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 手足症候群 / カテプシンC / 掌蹠角化 / パピヨン・ルフェーブル症候群 |
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| Outline of Final Research Achievements |
Sorafenib is an anticancer agent which lead to hand-foot syndrome characterized by hyperkeratosis.We speculated that cathepsin C (CTSC) is associated with the pathogenis of hand-foot syndrome. We confirmed CTSC expression in HaCaT（immortal keratinocyte cell line）cells decreased after adding Solafenib to culture medium for HaCaT. Furthermore, we administered Sorafenib CTSC knock out mice and wild type mice each, found that significant hyperkeratosis on soles was seen in CTSC knock out mice compared with wild.
We also researched that IL-4 and IL-13 stimulation increased CTSC expression in keratinocyte. The results will help treatment for hand-foot syndrome.
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| Free Research Field |
皮膚科学
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