2017 Fiscal Year Final Research Report
Comprehensive analysis of pathogenesis of cutaneous lymphoma
| Project/Area Number |
16K19709
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 皮膚悪性リンパ腫 / 菌状息肉症 / セザリー症候群 / IL-25 / cyclophilin A / CD147 / IL-10産生制御性B細胞 / CD137-CD137L |
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| Outline of Final Research Achievements |
We examined the expression and involvement of IL-25, cyclophilin A, CD147, CD137, CD137L, and IL-10-producing regulatory B cells (Bregs) in cutaneous T-cell lymphoma (CTCL).
We found that Th2 cytokines highly expressed in CTCL lesional skin induced IL-25 production by epidermal keratinocytes, which may in turn lead to formation of Th2-dominant microenvironment through the direct induction of IL-13 by tumor cells. We also found that interactions between CD147 expressed on the cell surface of CTCL tumor cells and CypA secreted by those cells promote CTCL development through promoting proliferation and survival of tumor cells. Moreover, in addition to CD137, aberrant CD137L expression was found on tumor cells of CTCL, and CD137-CD137L interactions promote cell proliferation and migration in CTCL cells. Furthermore, the development of IL-10-producing Bregs is impaired in patients with advanced mycosis fungoides and the number of Bregs was inversely correlated with disease severity markers.
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| Free Research Field |
皮膚科
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