2017 Fiscal Year Final Research Report
The role of neuromedin-U for mast cells activation.
| Project/Area Number |
16K19725
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Matsuo Yoshimi 広島大学, 医歯薬保健学研究科(医), 研究員 (50754355)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 神経ペプチド / ニューロメジンU / マスト細胞 / ヒスタミン |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the effects of NMU on the activation of mouse bone marrow-derived mast cells (BMMC), connective-tissue type mouse mast cells differentiated from BMMC (CTMC), and human skin derived mast cells (HSMC) in vitro. NMU induced the degranulation of CTMC and HSMC, but not BMMC, in a concentration-dependent manner. Although no or only slight NMU receptors (NMUR1) were expressed in CTMC and HSMC, MAS-related G protein coupled receptor-X2 (MRGPRX2) and Mrgprb2, mouse analog of MRGPRX2 were highly expressed in HSMC and in CTMC, respectively, but not in BMMC at mRNA level.
|
| Free Research Field |
Dermatology
|
