2017 Fiscal Year Final Research Report
The effect of PI3K pathway inhibitor and chemical epigenetics in angiosarcoma cells
| Project/Area Number |
16K19735
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Wada Makoto 京都府立医科大学, 医学(系)研究科(研究院), 学内講師 (90733080)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 血管肉腫 / PI3K阻害剤 / HDAC阻害剤 |
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| Outline of Final Research Achievements |
In this study, we evaluated the growth inhibition of PI3K inhibitor and epigenetics compounds in angiosarcoma cells. Histone deacetylase(HDAC) inhibitors suppressed the growth of angiosarcoma cells. HDAC inhibitors induced the cell-cycle arrest at G1 phase with the downregulated expression of cyclinD1 in ISOS-1 cells, and induced the cell-cycle arrest in G2/M phase with the upregulated expression of p21 in ISO-HAS cells. The combination of PI3K inhibitor and HDAC inhibitor additively suppressed the growth of angiosarcoma cells
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| Free Research Field |
皮膚腫瘍学
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