2017 Fiscal Year Final Research Report
Anti-inflammatory effect of Maresin 1 on skin inflamation
| Project/Area Number |
16K19744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
SAWADA Yu 産業医科大学, 医学部, 講師 (40551867)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | Maresin 1 / 乾癬 / IL-23 / IL-17 |
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| Outline of Final Research Achievements |
To examine anti-inflammatory effect of maresin 1 on skin inflammation, we used imiquimod-induced psoriasis model. Maresin 1 attenuates imiquimod-induced skin inflammation through regulating IL-17A production by γδT cell and Th17 cell. Maresin 1 downmodulates IL-23 receptor expression on these cells by RoRγt and IL-23 receptor internalization. Therefore, our results show maresin 1 inhibits imiquimod-induced skin inflammation through these mechanises. We plan to analyze additional anti-inflammatory effect of maresin 1 on other skin inflammatory disease models.
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| Free Research Field |
皮膚免疫
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