The development of new treatment strategy for dopamine supersensitivity psychosis.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19749
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Chiba University
• Principal Investigator: Oda Yasunori 千葉大学, 大学院医学研究院, 助教 (50770583)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: DSP / DRD2 / GSK3 / glutamate / NMDA receptor

Outline of Final Research Achievements

Western blot analysis revealed significant reduction in Striatal GSK-3α/β in DSP model rats compared with that in non DSP and controls, while there were no statistically significant difference in AKT, pGSK-3β.
On the other hand, glutamatergic signaling is relatively decreased to GABA in DSP rats. Our results also showed that excessive doses of haloperidol can induce striatal NMDAR hypofunction in non-DSP rats, which could prevent the formation of tardive dyskinesia but cause treatment resistance. In view of the need for therapeutic strategies for treatment-resistant schizophrenia, further research exploring our present findings is necessary.

Free Research Field

精神医学