Peripheral gene expression-based biological test for psychiatric diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima
• Principal Investigator: WATANABE Shin-ya 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (90563825)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 診断マーカー / うつ病 / 遺伝子発現 / 末梢血白血球

Outline of Final Research Achievements

We measured messenger ribonucleic acid expression levels of the aforementioned five genes in peripheral leukocytes in 17 patients with schizophrenia and 36 patients with bipolar disorder using quantitative real-time polymerase chain reaction (PCR), and we combined these expression data with our previous expression data of 25 patients with MDD and 25 controls. Subsequently, a linear discriminant function was developed for use in discriminating between patients with MDD and without MDD.This expression panel was able to segregate patients with MDD from those without MDD with a sensitivity and specificity of 64% and 67.9%, respectively.

Free Research Field

分子精神医学