Brain imaging study of neural activity of auditory hallucination in schizophrenia

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19772
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Nakamura Itta 九州大学, 医学研究院, 共同研究員 (90771460)
• Research Collaborator: ONITSUKA TOSHIAKI 九州大学, 医学研究院, 准教授 (00398059) ; HIRANO YOJI 九州大学, 医学研究院, 助教 (90567497) ; UENO TAKEFUMI 肥前精神医療センター, 臨床研究部長 (00441668) ; ORIBE NAOYA 肥前精神医療センター, 脳生理・神経画像, 研究室員 (70730498) ; KUGA HIRONORI ジョン-ホプキンス大学, 医学研究院 (50639903)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 統合失調症 / 幻聴 / γ帯域活動 / 脳磁図 / 聴性定常反応

Outline of Final Research Achievements

Auditory hallucination is one of the main symptoms of schizophrenic disorder and strong association with social life dysfunction has been shown. Many studies mentioned correlation with the degree of auditory hallucination symptoms and various auditory stimulus-inducing components in schizophrenia, while brain activities related to the start and end of hallucination of schizophrenic patients with intermittent hallucinations have not been cleared yet.
In this study, we investigated the immediate change of spontaneous brain activity and gamma band auditory steady-state response (ASSR), and found the possibility that the early component of ASSR varies depending on the presence or absence of auditory hallucination experience. In the future, considering further examination with a large sample, it is thought that it will lead to elucidation of the pathological condition related to the occurrence of the auditory experience.

Free Research Field

臨床神経生理