2017 Fiscal Year Final Research Report
Development of new MR lymphangiography by using Gd(III)-DTPA-Nanodiamond Particles
| Project/Area Number |
16K19861
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ナノダイヤモンド / MRI / リンパ管造影 / MRリンパ管造影 |
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| Outline of Final Research Achievements |
Lymphangiography was successfully performed in rabbits. Three-dimensional maximum intensity projection (3-D MIP) image on post-lymphangiographic multidetector CT in anteroposterior view clearly shows the lymphatic system in rabbits. Lymphangiography is feasible and the visibility of the lymphatic system on post-lymphangiographic MDCT in a rabbit model provides enough information for interventional radiologists to perform preclinical lymphatic interventions.
We found that Gd(III)-DTPA-nanodiamond (Gd-DTPA-Nd) particles formed persistent agglomerates in animal magnetic resonance imaging study. We must resolve the problem of persistent agglomerates to use Gd-DTPA-Nd particles in daily clinical works.
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| Free Research Field |
放射線医学
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