Optimization of Cellular Function Modifying Techniques for Therapy of Solid Tumor by using Radiolabeled Liposomes

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19877
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: Hamamichi Shusei 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 (60721686)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 放射性核種封入リポソーム / 放射性核種 / リポソーム / 固形がん / 内用療法

Outline of Final Research Achievements

Aim of this study was to compare accumulation levels of radiolabeled liposomes (i.e., In-111 EC, In-111 DTPA, etc.) in the tumor and other major tissues, and determine a technique that allowed increased tumor accumulation. Through analyzing radiolabeled liposomes by using multiple human cancer xenograft mice, we determined their biodistribution patterns, as well as necessity of these liposomes to be properly degraded in the RES for subsequent release of RI-ligand complexes. We also examined which transporter might be involved in the clearance of In-111 EC from the RES by treating RAW264 cells with various transporter inhibitors after phagocytosis of In-111 EC DSPG liposome. In addition, we determined that anti-cancer agent eribulin possessed a capacity to increase microvessel density in the tumor, as well as enhance tumor accumulation of radiolabeled liposome and anti-tumor effect of Doxil (liposomal anti-cancer agent).

Free Research Field

核医学