The preservation of the marginal graft using hydrogen super rich saline

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19891
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: OGAWA ERI 京都大学, 医学研究科, 特定助教 (30440506)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 虚血再灌流障害 / 肝移植後の肝癌再発 / 肝境界グラフト / 水素含有臓器保存液 / ラット同所性全肝移植

Outline of Final Research Achievements

Our basic data has not shown that the effect of hydrogen super rich saline in our hepatic pedicle clamping-induced ischemic reperfusion injury. We established orthotopic liver transplantation model in rat. All the grafted rats have survived for more than one hundred days. We have tried to make recurrence model for the rat liver transplantation for hepatocellular carcinoma. We have planned to verify the reduction effect of ischemic reperfusion injury by hydrogen super rich saline on the marginal graft model such as small-for-size graft and fatty liver transplantation model in addition to this model.

Free Research Field

肝移植