Mechanism of high malignant potential with recurrence of hepatocellular carcinoma after radiofrequency ablation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19895
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: YAMADA Shinichiro 徳島大学, 大学院医歯薬学研究部(医学系), 徳島大学専門研究員 (30579884)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 肝細胞癌 / ラジオ波焼灼療法(RFA) / HIF-1 / 癌幹細胞 / EMT

Outline of Final Research Achievements

Regarding radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), local recurrence is related to poor prognosis. With resected specimen, we aimed to elucidate the mechanism of high malignant potential with recurrence of hepatocellular carcinoma after radiofrequency ablation. Eighty-eight patients of HCC were divided into 2 groups; RFA group (n=10), hepatic resection was performed after local recurrence, and non-RFA group (n=78), hepatic resection was performed without prior RFA. In RFA group, mRNA of HIF-1, EpCAM, EMT marker(TGF-β, Twist, Snail-1, Vimentin), were high compared with non-RFA group. This study indicated that local recurrence after RFA accelerate HIF-1 expression, and malignant potential is enhanced through expressions of cancer stem cell and EMT markers.

Free Research Field

医歯薬学