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2017 Fiscal Year Final Research Report

Elucidation of Molecular Mechanisms of Biological Heterogeneity and Its Clinical Application in Triple-Negative Breast Cancer.

Research Project

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Project/Area Number 16K19899
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

YAMASHITA Nami  九州大学, 大学病院, 助教 (60608967)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywordsトリプルネガティブ乳癌 / EMT / collective invasion / E-cadherin / vimentin / BRCAness
Outline of Final Research Achievements

The treatment of patients with TNBC has been challenging due to the absence of
these molecular targets and the heterogeneity of the disease. Multiple mechanisms have emerged to address how epithelial breast tumors invade. The aim of our study is to elucidate the clinical importance of the expression of E-cadherin and vimentin in breast cancer. Co-expression of E-cadherin and vimentin seems to be associated with the most aggressive phenotype and poorest prognosis in breast cancer. Moreover, co-localization of E-cadherin and vimentin within the same breast cancer cells indicates the existence of heterogeneity in breast cancer invasion.The therapeutic targeting of aggressive subpopulation may provide a positive impact on improving the outcomes of breast cancer patients.

Free Research Field

乳腺腫瘍学

URL: 

Published: 2019-03-29  

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