2017 Fiscal Year Final Research Report
Functional analysis of Stomatin like protein 2, a new prognostic factor for pancreatic cancer, and verify the relevance to prognosis
| Project/Area Number |
16K19911
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | SLP-2 / stomatin / 膵癌 / 肝転移 / EMT / ミトコンドリア |
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| Outline of Final Research Achievements |
Functional analysis was performed using two types of pancreatic cancer cell lines prepared by shRNA technique. We examined the susceptibility of anticancer drugs, but no significant results were obtained. However, in the cell line that suppressed the expression of SLP-2, the migratory ability and invasive ability were remarkably decreased, indicating that the EMT was controlled. In the liver metastasis model using mouse, it was shown that the number of liver metastasis was significantly decreased in the SLP-2 suppressed ccells. From the above, it is suggested that SLP-2 may regulate the invasive ability and metastasis of cancer cells via EMT.
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| Free Research Field |
外科
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