2017 Fiscal Year Final Research Report
Exosomal microRNA transfer regulates cell proliferation and tumor progression in pancreatic cancer
| Project/Area Number |
16K19915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
Takahashi Makoto
Nakata Shinichiro
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | エクソソーム / 膵癌 |
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| Outline of Final Research Achievements |
We evaluated exosomes isolated from pancreatic cancer-derived cells. CD 63 was highly expressed in BxPC-3、CFPAC-1、Panc-1 cells, on the other hand CD 63 was slightly expressed in MIA PaCa-2、AsPC-1 cells. These results suggest that exosome production is depended on pancreatic cancer-derived cell.Furthermore, we detected exsomal RNA form pancreatic cancer-derived cells as well as serum form pancreatic cancer patients. We could not detect specific miRNA from various exosomal RNA.
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| Free Research Field |
肝胆膵
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