Functional analyses and developments of new therapies targeting LSD1 in gastrointestinal cancers

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19941
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: KOSUMI Keisuke 熊本大学, 医学部附属病院, 非常勤診療医師 (50594884)
• Research Collaborator: BABA Yoshifumi 熊本大学, 大学院生命科学研究部, 講師 (20599708) ; HARADA Kazuto 熊本大学, 医学部附属病院, 非常勤診療医師 (70608869) ; YAMAMURA Kensuke 熊本大学, 医学部附属病院, 非常勤診療医師 (10816507)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: がん代謝 / 消化器癌 / バイオマーカー / エピジェネティクス / がん免疫

Outline of Final Research Achievements

The aim of the current study is to investigate the significance of Lysine Specific Demethylase-1 (LSD1) using global human population-based database, and contribute to the development of the new treatments. No association was observed between tumor LSD1 expression, and PIK3CA mutation, NRF2, CD8+ T-cell density, FOXP3+ T-cell density, PD-L1, IDO1, or tumor-infiltrating lymphocytes (P > 0.14). However, we found the significant inverse association of LSD1 with LINE-1 methylation level and peritumoral lymphocytic reaction (P = 0.0019 and P = 0.017, respectively). Our findings support the possible influence of LSD1 on epigenetic change and anti-tumor immunity.

Free Research Field

外科腫瘍学