2017 Fiscal Year Final Research Report
Exploitation of a liquid biopsy system using circulating tumor DNA in esophageal cancer patients
| Project/Area Number |
16K19952
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
Endo Fumitaka 岩手医科大学, 医学部, 助教 (70714442)
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | circulating tumor DNA / circulating free DNA / 食道癌 / digital PCR / 次世代シーケンサー |
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| Outline of Final Research Achievements |
In this study, we performed and established tumor burden monitoring with ctDNA for esophageal squamous cell carcinoma patients treated with either surgery or chemotherapy, using next generation sequencer for mutation detection in primary tumors and digital PCR for ctDNA monitoring in blood samples.
And combinatory procedure of BCT and CPT would be one of the most practical approaches for collection and storage of samples collected during extended follow-up.
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| Free Research Field |
消化器外科学、分子生物学
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