Evaluation of Optimal Aortic Bioprosthetic Valve Based on Coronary Artery Flow Analysis

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K19970
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Mitsuru Yuzaki 和歌山県立医科大学, 医学部, 助教 (80405448)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 大動脈弁狭窄症 / TAVR

Outline of Final Research Achievements

4D flow MRI was used to detect blood flow at the ostium of the left coronary artery in patients after surgical aortic valve replacement. A theoretical equation for analyzing coronary blood flow was developed to compare two types of aortic bioprosthetic valve: bovine pericardial valve and porcine aortic valve.
However, radial catheter aortic valve intervention (TAVI) was introduced during the study period. It became difficult to collect two patients with the same background. It was considered necessary to analyze the blood flow of the TAVI valve. It was possible to make the 3D simulation model from CT before and after the operation, and it was possible to construct the basis of the examination from the knowledge got until now in respect of blood flow analysis of the TAVI valve.

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

大動脈弁狭窄症は加齢に伴い増加している。従来行われてきた外科的大動脈弁置換術に対して径カテーテル的大動脈弁置換術（TAVI）が爆発的に増加している。低侵襲性は疑いようもないが、従来の人工弁置換術とは埋め込み方が大きく違うことから、耐用性や特有の問題があることも事実である。
本研究では、TAVIで埋め込んだ人工弁の結構動態をシミュレーションモデルで検討する基礎を確立することが出来た。