2017 Fiscal Year Final Research Report
Study on lung cancer immunotherapy incorporating inhibition of derivation of CAFs progenitor from bone marrow
| Project/Area Number |
16K19977
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory surgery
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | がん間質細胞 |
|---|
| Outline of Final Research Achievements |
CAFs in lung cancer tissue were increased in COPD. The degree of emphysematous change would be more related by the frequency of CAFs. Among the various COPD parameters, LAA would be more related to the number of CAFs in tumor microenvironment. Because parameters obtained from the pulmonary function test and smoking index are often affected by the skill and memory of the patients, LAA might be more reliable to predict the frequency of CAFs. These results suggested that intervention in COPD might be one of the CAFs targeted strategies.
|
| Free Research Field |
腫瘍微小環境
|
